… we explored the benzimidazolo-thiazole core scaffold. The … ring was replaced by smaller
heterocycles. Herein, we describe … We started our optimization program with the replacement of …

… of the optimized derivative compounds have produced CXCR3 … of two high affinity CXCR3
antagonists were shown, which … nitrogen atoms in the heterocyclic scaffold of the compound …

… of biologically important heterocyclic compounds, herein we … With the optimization of
reaction conditions, further study of … the above-mentioned optimized reaction conditions in good …

… Nitrogen containing compounds are very important heterocyclic derivatives in the field of …
J et al, Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3, …

… Fused heterocycles with bridgehead nitrogen atoms are important scaffolds commonly used
… for the subsequent optimization study. The results of the optimization study are shown in …

… Using the these starting materials and our optimized conditions (entry 8, Table 1), the scope
of the protocol was assessed. Twenty dihydropyrazinoquinazolinones were prepared with …

… of the most important N-fused bicyclic heterocycles because of their presence in numerous
… such kind of heterocycles and expanded their scope in the field of medicinal chemistry. (8) …